Superposition options

There is now an option in V6.9 that allows users to conduct Superposition runs with different doses and dosing intervals.

Unfortunately, there are certain profiles that are so poorly defined, for a variety of reasons, such that full modelling of the data is inapproriate. In these circumstances it can be useful to predict repeat dose profiles based on half-life alone. One of the most common types of profiles that cause problems are after oral dosing.

The example below (copied directly from the PCModfit 'Superposition' spreadsheet) shows the results for a predicted repeat dose scenario (10 doses) based on a half life (user selected points, n=7) of ca. 3.5 h (program generated) using different doses and dosing intervals. The spreadsheet is updated when the module is run and shows considerable information in the form of plots and Cmin, Cmax and AUC after each dose. Another plot that can be useful for a variety of reasons is shown below (1st and last dose). There is also a summary table that specifies the actual data point times for the 1st and last doses. This can save a lot of time as to extract these manually from the thousands of values calculated can be very prolonged.