Version 6.9 is now available and with an updated manual (for information, there are currently >4500 users of the software).
The Superposition option in V6.9 has undergone a significant update and now permits users to conduct runs with different doses, dosing intervals and with more extensive output and plots with more precision (thanks to very helpful suggestions by Angus McLean, Ph.D., in the USA and Dr med. Christian de Mey (from ACPS - Applied Clinical Pharmacology Services in Germany).
NCA intercept value is now displayed on the graph, in the Spreadsheet and txt results file. Useful for C0 values with bolus i.v. data and in other calculations.
Version 6.9 now has a three-compartment oral model not only for single and repeat dose simulations but also for Modelling data sets (Model numbers 42 and 43 with and without lag-time, respectively). Also, minor modifications for repeated dose simulations with user defined Differential Equations allowing varying doses, intervals and models in any sequence.
For one of the modelling algorithms (Simplex) a bug was found (typo) but now corrected, which caused the program to get stuck with some near perfect data sets.
The Loo-Riegelman Deconvolution module was rewritten in V6.7 with more accuracy throughout (J. Pharm. Sci. 72, 7, July 1983) and has test profiles to show their validity (1, 2 and 3 compartment models). This has undergone further testing. There are other updates still being worked on besides general tidying up, that will allow data modelling with user defined differential equations in real-time, without the need to recompile the program. The SD and RD simulators now have a facility for users to enter their own time values (in addition to the usual output). Manual updated for all additions/modifications and an extra section for NCA with examples explaining how zero time points are dealt with for AUC calculations. Version 6.9 and onwards will now regularly check the PCModfit Website automatically for any future updates and will notify the user at run-time if any are available.
PCModfit runs with Excel 2013/2016/2019 and other versions (for Windows 7, 8, 8.1 and 10).
The non-PC version was published in Biopharmaceutics and Drug Disposition Vol. 11, No. 6, 1990, p.477-497. The author has and is still using PCModfit for numerous Phase I and II studies for domestic and international companies.
PCModfit is a pharmacokinetics program with the intensive numerical parts (modelling and differential equation simulations) are written in Fortran for speed. Most of the computer source code has been rewritten since publication to ensure more accuracy and versatility. The program will only run on a local computer - not a network server and each installation has its own unique licence. PCModfit is mentioned as a reference in over 200 publications to date (ca. 50 are shown on the NCA menu item for information). The instructions for each option are shown on the individual Tabs within the Excel spreadsheet.
User licenses are free and so is the new manual (as a PDF file) in the C:\PCModfit V6.9\Manual\ directory (after installation).
The setup program is available from the menu item Download, at the top of this page where some
guidance on installation is provided.