Non-Compartmental Analysis (and publication list)
The model independent option (NCA) in PCModfit allows the user to analyse time-concentration data within Excel. The user can easily select (or deselect) the number of data points interactively using a high resolution graphics window to estimate half-lives, tmax, Cmax and various types of AUC and AUMC. The results are directly and neatly transferred to the NCA Excel spreadsheet or as text files so further editing can be conducted. High quality plots of the data and fitted line can easily be imported into Word etc. Both pictures and text results are stored in the 'Results' folder in the PCModfit directory
There are also extensive help facilities within each option. A clipped snippet of what the user is likely to see is shown below for information.
Since the latest version was released (V6 onwards), PCModfit NCA has tested using published data from the literature and the results show essentially the same values as two other programs i.e. WinNonLin and PKSolver.
Computer methods and programs in biomedicine 9 9 (2010) 306-314 PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel Yong Zhanga,1, Meirong Huoa,1, Jianping Zhoua,*, Shaofei Xieb.
The data and results are shown in the Ref. and the user should try the NCA data for comparison themselves.
Shown below for information...
A quick search of the internet suggests that PCModfit has been referenced numerous times in publications and without a detailed look, over 40 were found for information only (below).