Version 6.7 is now available and with an updated manual.

Latest news (10th June 2019)

Version 6.7 now has an option for conducting Superposition repeat dose profiles with varying dosing intervals (thanks to a suggestion by Angus McLean) with more precision. Also, slightly revamped, repeated dose simulations can be conducted with user defined Differential Equations allowing varying doses, intervals and models in any sequence. The Loo-Riegelman Deconvolution module has been rewritten with more accuracy throughout, using Wagner's exact equations (J. Pharm. Sci. 72, 7, July 1983) and has test profiles to show their validity (1, 2 and 3 compartment models). A three-compartment oral model has been added, by request, for single and repeat dose simulations. This has been checked against the Differential equation module and the results are identical.

Check boxes have been added to NCA and Deconvolution to make selections quicker and easier (not having to enter an asterisk character). The NCA has been cross-checked, by independent users, with other programs to demonstrate its validity and accuracy. There is now a 'Models' button on the Modelling sheet (next to the 'Run' button) as a quick aide-memoir for available model numbers. There are other updates still being worked on, that will allow data modelling with user defined differential equations in real-time, without the need to recompile the program.

PCModfit runs with Excel 2013/2016 and other versions (for Windows 7, 8, 8.1 and 10).

The non-PC version was published in Biopharmaceutics and Drug Disposition Vol. 11, No. 6, 1990, p.477-497. The author has and is still using PCModfit for numerous Phase I and II studies for domestic and international companies.

PCModfit is a pharmacokinetics program with the intensive numerical parts (modelling and differential equation simulations) are written in Fortran for speed. The program will only run on a local computer - not a network server and each installation has its own unique licence. PCModfit is mentioned as a reference in over 150 publications to date. The instructions for each option are shown on the individual Tabs within the Excel spreadsheet.

User licenses are free and so is the new manual (as a PDF file) in the C:\PCModfit V6.7\Manual directory (after installation).

The setup program is available from the menu item Download, at the top of this page where some guidance on installation is provided.

Last Revised: 10-June-2019

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